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World’s First Genetically-Edited Pig Kidney Transplant Performed at Massachusetts General Hospital Massachusetts General Hospital (MGH) has achieved a groundbreaking milestone in medicine by successfully performing the world’s first genetically-edited pig kidney transplant into a living recipient, 62-year-old Richard "Rick" Slayman, who suffers from end-stage kidney disease (ESKD). The procedure utilized a pig kidney with 69 genetic modifications, designed to improve compatibility with humans, using CRISPR-Cas9 technology. This innovative surgery, conducted under FDA compassionate use guidelines, aims to address the critical shortage of donor organs. Mr. Slayman, who previously received a human kidney transplant in 2018, resumed dialysis in 2023 after his transplant failed. The pig kidney transplant has provided a new lifeline for him while paving the way for future advancements in xenotransplantation. The success is the result of decades of research by MGH and co...

Hi Folks!! Follow our blog on  Instagram Introduction to Transcriptomics The transcriptome represents all RNA molecules, including messenger RNA (mRNA), ribosomal RNA (rRNA), transfer RNA (tRNA), and non-coding RNA, within a cell or a population of cells at a particular time. Unlike DNA, which remains relatively stable, RNA levels vary significantly between cells and across different conditions, reflecting the dynamic nature of gene expression. Transcriptomics provides insights into how genes are turned on or off, how cells respond to external stimuli, and how different cell types or tissues function. Studying transcriptomics has become essential in various areas such as developmental biology, cancer research, neuroscience, and immunology. Scientists can understand gene regulation, cellular differentiation, and disease mechanisms by investigating RNA transcripts. Transcriptomics Techniques 1. Microarrays Microarrays were one of the first high-throughput technologies for analyzing g...

Hi Folks!! Follow our blog on  Instagram Introduction to Genomics Genomics is the branch of biology that studies the structure, function, evolution, mapping, and editing of genomes. A genome is the complete set of DNA, including all of its genes, in an organism. This field of study, emerging rapidly over the last few decades, has revolutionized our understanding of biology and opened new avenues in fields like medicine, agriculture, and environmental science.  Development of Genomics The field of genomics can be traced back to the discovery of DNA as the genetic material of living organisms. In 1953, James Watson and Francis Crick revealed the double helix structure of DNA, marking a milestone in biology. Following this, the development of DNA sequencing technologies in the 1970s by Frederick Sanger allowed for the identification of the precise order of nucleotides (adenine, guanine, cytosine, and thymine) in DNA. These innovations laid the groundwork for the Human Genome Proj...