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Phenylketonuria Phenylketonuria (PKU) is the most common metabolic disorder in amino acid metabolism.. The incidence of PKU is 1 in 10.000 births. It is due to the deficiency of the hepatic enzyme, phenylalanine hydroxylase. caused by an autosomal recessive gene. In recent years, a variant of PKU-due to a defect in dihydrobiopterin reductase (relatively less)-has been reported. This enzyme deficiency impairs the synthesis of tetrahydrobiopterin required for the action of phenylalanine hydroxylase  The net outcome in PKU is that phenylalanine is not converted to tyrosine.  Phenyl alanine metabolism in PKU :- Phenylketonuria primarily causes the accumula- tion of phenylalanine in tissues and blood, and results in its increased excretion in urine. Due to disturbances in the routine metabolism, phenyl. alternate pathways resulting in the excessive production alanine is diverted to of phenylpyruvate, phenylacetate, phenyllactate and phenylacetylglutamine. All these metabolites a

Hi Folks!! Follow me on instagram https://instagram.com/labinthebox227?igshid=ZDdkNTZiNTM= Top strongest acids ever -PART 2 From this point, acids are called "Super Acids". Since they can't be measured directly, they will be measured  on the Hammett Acidity Scale (H0). Chlorosulphuric Acid:- It is 8,800,000 times stronger than Hydrochloric Acid. First Superacid on this acid it is a beast(-12.78H0).It reacts violently with Water.It yields Sulphuric Acid and Hydrogen Chlorine in the process. Basically it turns into less powerful acid. In this process it also releases acidic fumes. Perchloric Acid:- It is 2.2 times stronger than Chlorosulphuric acid. Perchloric acid is a component in rocket fuel. Outside of that, it is commonly use din industrial purposes, and for a good reason perchloric acid is highly toxic, and when it's in crystal form, it can explode. Inhalation of its fumes can result in brain or lung damage and death (About -13H0). Trifilic Acid:- It is 100 times

We will measure acidity in pKa.Lower the pKa, higher the acidity URIC ACID :- Uric Acid is a product of metabolic breakdown Also it can be found in Urine (5%-25%). Obviously it is not a powerful acid.It has pKa level of only 5.6. CITRIC ACID:- It is 8.4 times stronger than Uric acid.For instance lemon juice has only 8% of citric acid.It has only pKa value of only 4.7.It is used to dissolve rust and passivate Stainless steel.Also it mainly used in food and beverages . HYDROFLUORIC ACID:- It is 67 times stronger than Citric Acid.Before large batches of Hydrofluoric acid made in 1700s.Chemists told that it is extremely Dangerous.Even it could melt glass and Metal.It is very toxic.If you get it on your own skin,it can cause Heart attack (It reacts with Blood calcium).It also destroys nerves.We won't be feel anything if our bone melts this disturbing acid.The average pKa if Hydrofluoric acid is 3.16. NITRIC ACID:- It is 67000 times stronger than Hydrofluoric acid.It is used

Today I am gonna talk about the general topic that most of the upcoming college students have a knowledge about that term but no idea about it.Its the term named "COUNSELLING". If you wanna pursue Engineering through Government Quota,You can come through counselling.However some people book their seats before the result comes.If you are really confident about the cut off ,You can get good colleges at your choice in Round 1 or Round 2. Counselling will have four rounds.They divide the students into 4 rounds based on the rank list. In each round, you have 3 days as the selection time .In that time, you can discuss with your parents or your career advisor and select your college.After 3 days ,You'll get temporary allotment in which you can decide whether you are satisfied to that alloted college.If you are satisfied , you'll get the permanant allotment.If you are not satisfied with your alloted college,You'll be moved to next round.After you got the Perma