HAEMOPHILIA (X-LINKED RECESSIVE DISORDERS SERIES 2)

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Hemophilia A is a genetic disorder caused by a deficiency of clotting factor VIII. It is the most common type of hemophilia, representing about 80% to 85% of all cases. Clotting factor VIII is crucial for the blood to form clots and prevent excessive bleeding. 

Key points about Hemophilia A:

1. Genetic Inheritance: Hemophilia A is inherited in an X-linked recessive pattern primarily affecting males. Females can be carriers, but they typically do not show symptoms.

2. Symptoms: Individuals with hemophilia A may experience prolonged bleeding after injuries, easy bruising, and spontaneous bleeding. Joint bleeding is common and can lead to chronic joint disease if not properly managed.

3. Treatment: The mainstay of treatment for hemophilia A involves replacing the missing factor VIII through intravenous infusions. This can help control bleeding and prevent complications.

4. Factor VIII Replacement Therapy: Recombinant factor VIII or plasma-derived factor VIII concentrates are used for replacement therapy. The goal is to maintain a sufficient level of factor VIII in the blood to support normal clotting.

5. Prophylactic Treatment: Some individuals with severe hemophilia A may receive prophylactic (preventive) factor replacement to minimize the risk of spontaneous bleeding episodes.

6. Management: Hemophilia A requires lifelong management, and individuals with the condition often work closely with healthcare professionals to develop a treatment plan tailored to their needs.

People with severe hemophilia may develop life-threatening bleeding, but they’re more likely to develop bleeding in their muscles and joints.






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