HAEMOPHILIA (X-LINKED RECESSIVE DISORDERS SERIES 2)

-
Hi Folks!! Follow our blog on Instagram LAB IN THE BOX


Hemophilia A is a genetic disorder caused by a deficiency of clotting factor VIII. It is the most common type of hemophilia, representing about 80% to 85% of all cases. Clotting factor VIII is crucial for the blood to form clots and prevent excessive bleeding. 

Key points about Hemophilia A:

1. Genetic Inheritance: Hemophilia A is inherited in an X-linked recessive pattern primarily affecting males. Females can be carriers, but they typically do not show symptoms.

2. Symptoms: Individuals with hemophilia A may experience prolonged bleeding after injuries, easy bruising, and spontaneous bleeding. Joint bleeding is common and can lead to chronic joint disease if not properly managed.

3. Treatment: The mainstay of treatment for hemophilia A involves replacing the missing factor VIII through intravenous infusions. This can help control bleeding and prevent complications.

4. Factor VIII Replacement Therapy: Recombinant factor VIII or plasma-derived factor VIII concentrates are used for replacement therapy. The goal is to maintain a sufficient level of factor VIII in the blood to support normal clotting.

5. Prophylactic Treatment: Some individuals with severe hemophilia A may receive prophylactic (preventive) factor replacement to minimize the risk of spontaneous bleeding episodes.

6. Management: Hemophilia A requires lifelong management, and individuals with the condition often work closely with healthcare professionals to develop a treatment plan tailored to their needs.

People with severe hemophilia may develop life-threatening bleeding, but they’re more likely to develop bleeding in their muscles and joints.






Comments

Post a Comment

Popular posts from this blog

ONCOLOGY_2_MELANOMA

-
Image
Hi Folks!! Follow our blog on Instagram  LAB IN THE BOX MELANOMA What is Melanoma? Melanoma is a form of skin cancer arising from melanocytes, the pigment-producing cells in the skin. While it is less common than other skin cancers, it is significantly more dangerous due to its ability to spread (metastasize) to other parts of the body if not caught early. Causes and Risk Factors The primary cause of melanoma is exposure to ultraviolet (UV) radiation from the sun or tanning beds. Factors that increase the risk of melanoma include: - Fair Skin : Less melanin provides less protection from UV radiation. - History of Sunburns : Severe, blistering sunburns, especially in early life, increase risk. - Excessive UV Exposure : Frequent use of tanning beds or extensive sun exposure. - Family History : A family history of melanoma increases risk. - Moles : Having many moles or unusual moles can be a risk factor. - Weakened Immune System : Immunocompromised individuals are at higher risk. Sign...
Read more

Warmer climate may Drive Fungi to be more dangerous to our Health!!

-
Image
  Warmer climate may Drive Fungi to be more dangerous to our Health!! The world is filled with tiny creatures that sometimes found it delicious. Bacteria and viruses are so obvious that they are pathogenic . However recent news from Duke University School of medicine found that raised temperature  cause a pathogenic fungus known as Cryptococcus deneoformans to turn its adaptative responses into overdrive. This increases its number of genetic changes, some of which might presumably lead to higher heat resistance, and others perhaps toward greater disease-causing potential . " Fungal diseases are on the rise, largely because of an increase in the number of people who have weakened immune systems or underlying health conditions," Gusa said. But at the same time, pathogenic fungi may be adapting to warmer temperatures as well. Materials  provided by  Duke University .                             ...
Read more

History of Biotechnology

-
Image
HISTORY OF BIOTECHNOLOGY: People have been harnessing biological processes to improve their quality of life for some 10,000 years, beginning with the first agricultural communities. Approximately 6,000 years ago, humans began to tap the biological processes of microorganisms in order to make bread, alcoholic beverages, and cheese and to preserve dairy products. But such processes are not what is meant today by biotechnology, a term first widely applied to the molecular and cellular technologies that began to emerge in the 1960s and ’70s. A fledgling “biotech” industry began to coalesce in the mid- to late 1970s, led by Genentech, a pharmaceutical company established in 1976 by Robert A. Swanson and Herbert W. Boyer to commercialize the recombinant DNA technology pioneered by Boyer, Paul Berg, and Stanley N. Cohen. Early companies such as Genentech, Amgen, Biogen, Cetus, and Genex began by manufacturing genetically engineered substances primarily for medical and environmental uses. For ...
Read more